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December 2, 2025

Melatonin: Is Long-Term Use Linked to Heart Failure Risk?

Melatonin: Is Long-Term Use Linked to Heart Failure Risk?
Photo Credit: Unsplash.com

Melatonin is a naturally occurring hormone that regulates our sleep-wake cycle. For years, it’s been a go-to remedy for insomnia and jet lag. However, as its popularity continues to grow, new concerns are emerging about the long-term effects of melatonin supplementation, particularly its potential link to heart health. Recent studies suggest that while melatonin is widely considered safe in the short term, its prolonged use could carry some risks, especially for individuals with pre-existing cardiovascular conditions. In this article, we explore whether long-term melatonin use may be linked to heart failure risk and what you need to know.

The Growing Popularity of Melatonin Supplements

Melatonin supplements are marketed as a quick fix for sleep problems. Easy to find in health stores and online, melatonin is often considered a safer alternative to prescription sleep aids. Research shows that nearly 3 million Americans use melatonin supplements, with a significant number of those people relying on it for extended periods. The promise of a good night’s sleep without side effects seems too good to pass up.

But while melatonin helps many individuals fall asleep faster, does it come with hidden risks when used regularly? This question is becoming increasingly important as more people use melatonin supplements for months or even years.

How Melatonin Works in the Body

Before diving into its potential risks, it’s important to understand how melatonin functions in the body. This hormone is produced naturally by the pineal gland in response to darkness, signaling the body that it’s time to sleep. When we consume melatonin supplements, it boosts the body’s ability to fall asleep by mimicking this natural process.

While melatonin is largely associated with improving sleep, the hormone is also involved in other physiological functions, including the regulation of blood pressure, immune function, and the cardiovascular system. It is here that researchers are beginning to explore how melatonin might impact heart health, particularly when used over a long period.

Is There a Link Between Melatonin and Heart Failure?

Recent studies have raised concerns about the long-term use of melatonin and its potential effects on the cardiovascular system. According to some experts, prolonged use of melatonin could impact heart health, particularly for those with existing heart conditions.

While research is still limited, some studies suggest that melatonin may influence blood pressure regulation and vascular tone, which could contribute to cardiovascular issues in the long run. One theory is that melatonin may alter the balance of hormones that control blood pressure, such as cortisol, which could lead to an increased risk of high blood pressure and, over time, heart failure.

Furthermore, while melatonin is often prescribed to patients to improve sleep, its long-term effects on those with underlying health issues, such as heart disease, are not well understood. Studies conducted on animals have shown some evidence of melatonin’s potential to cause adverse effects on heart rate variability and the function of the heart muscle. These findings suggest that melatonin, while safe in the short term, may carry risks for individuals with certain heart conditions.

Melatonin and High Blood Pressure: A Dangerous Combination?

Melatonin: Is Long-Term Use Linked to Heart Failure Risk?
Photo Credit: Unsplash.com

One of the most concerning potential side effects of melatonin is its effect on blood pressure. In some cases, melatonin has been shown to lower blood pressure, which can be beneficial for people with hypertension. However, for others, especially those who are already on blood pressure medications, melatonin may have an unpredictable impact on blood pressure levels.

Studies have found that melatonin supplements can interact with antihypertensive medications, potentially lowering blood pressure too much or causing it to fluctuate. This could exacerbate heart conditions, leading to complications such as arrhythmias, or even increase the risk of a heart attack or stroke. For this reason, people with high blood pressure or other heart conditions should use melatonin supplements with caution and only under the supervision of a healthcare professional.

Who Should Be Cautious About Long-Term Melatonin Use?

If you are considering using melatonin long-term, it’s essential to weigh the potential risks. People with pre-existing cardiovascular conditions, such as heart failure, arrhythmias, or high blood pressure, should be especially cautious. These individuals may be at greater risk of adverse effects from melatonin due to the hormone’s impact on heart rate and blood pressure regulation.

Anyone who is already on medications for heart disease or high blood pressure should consult with their doctor before starting melatonin supplementation. Since melatonin can interfere with other medications, it’s important to ensure that it will not negatively affect your treatment plan.

Alternative Sleep Aids and Heart Health

If you’re concerned about the long-term use of melatonin, there are several alternatives that may be less likely to impact heart health. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a non-medication treatment that focuses on changing thoughts and behaviors around sleep, offering a more sustainable and healthier solution for chronic sleep issues. Additionally, natural remedies such as valerian root, chamomile, and lavender have been used for centuries to promote relaxation and sleep without the potential side effects associated with melatonin.

Exercise, meditation, and a healthy diet are also key components of improving sleep quality and supporting overall cardiovascular health. Establishing a regular sleep routine and reducing caffeine intake before bedtime can further improve your ability to sleep soundly without the need for supplements.

The Bottom Line: Should You Be Concerned About Heart Failure Risk?

While melatonin is widely regarded as a safe, short-term solution for sleep problems, it’s essential to be mindful of the potential risks associated with long-term use, particularly if you have heart disease or are at risk for cardiovascular issues. As with any supplement, moderation is key, and consulting with a healthcare provider can help you make the best decision for your health.

Before using melatonin long-term, consider other methods of improving sleep and explore safer alternatives that won’t compromise your heart health. If you do choose to continue using melatonin, make sure to monitor its effects on your body, especially if you have any pre-existing health conditions.

Disclaimer: The information provided in this article is for general informational purposes only and is not intended as medical advice. If you are considering using melatonin or have concerns about its effects on your health, particularly in relation to heart disease or other cardiovascular conditions, please consult with a healthcare professional. Only a medical provider can offer personalized advice and determine the most appropriate treatment based on your specific health needs. Always follow the guidance of your doctor regarding the use of supplements or medications.

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