By: Erica Bailey
Alzheimer’s disease, a neurological disorder, has posed significant challenges in both understanding and treatment. In this context, Suneeta Modekurty‘s contributions stand out, particularly in using bioinformatics to seek a cure for Alzheimer’s. With the United States grappling with the impact of this disease, where more than 6 million Americans are living with Alzheimer’s as of 2021, and projections showing this number rising to nearly 13 million by 2050, the economic and emotional toll is substantial. The cost of Alzheimer’s and other dementias in the U.S. was about $355 billion in 2021, and this is expected to rise to over $1.1 trillion by 2050. Additionally, more than 11 million Americans provided unpaid care for people with Alzheimer’s or other dementias in 2020, underlining the heavy burden on caregivers.
Modekurty, with her solid bioinformatics background, embarked on a groundbreaking research journey at Indiana University. Her research thesis, “Integrated Correlation Analysis of Proteomics and Transcriptomics Data in Alzheimer’s Disease,” delved deep into the molecular mechanisms of Alzheimer’s. She used RNA sequencing to compare miRNA and mRNA expressions in Alzheimer’s patients against healthy individuals. Her findings revealed significant correlations in genes and miRNAs involved in the disease’s pathology, highlighting pathways related to synaptic function and neurodegeneration. Crucial genes like CALM3, PPP3CB, and ITPR1, along with novel miRNAs previously unreported in Alzheimer’s pathogenesis, were identified.
Modekurty’s research provided unprecedented insights into Alzheimer’s molecular landscape. Her network analysis pinpointed key upregulated miRNAs, suggesting new potential targets for therapeutic interventions. The intricacy of her work in decoding the complex genetic interactions in Alzheimer’s disease has set a new precedent in this field. Reflecting on her research, Modekurty stated, “The journey through the molecular intricacies of Alzheimer’s disease has been both challenging and enlightening. Unraveling the complex network of genes and miRNAs opens new avenues for understanding and potentially treating this debilitating condition.”
This kind of research is integral to the development of effective therapeutic strategies and in reducing the burden of Alzheimer’s disease on individuals, families, and healthcare systems. As Alzheimer’s prevalence continues to grow, the importance of such detailed and focused research cannot be overstated, representing hope in the fight against this debilitating condition.
Modekurty’s transition to Centene Corporation, a leading healthcare company, saw her apply her bioinformatics skills in a different but equally impactful manner. As a Business Intelligence Developer, she was instrumental in developing the 278 product (EDI) dashboard. This tool revolutionized data analytics at Centene. Her innovative solutions include automating Excel file downloads, streamlining processes, and enhancing efficiency. Her role in introducing Agile practices and fostering a culture of continuous improvement in data visualization and analytics underscores her ability to integrate scientific understanding with practical innovation.
Suneeta Modekurty’s journey from a bioinformatics student to a business analytics leader demonstrates the transformative power of interdisciplinary skills in healthcare. Her research and professional contributions reflect a commitment to advancing our understanding and treatment of Alzheimer’s disease, significantly contributing to a more informed and healthier society.